It would begin by admitting that there are certain things we simply can't control. As many others have stated, you mitigate the best you can and accept that there are going to be losses. If the goal really is to get the other 50% vaccinated, how about reaching out to them instead of treating them like the unclean masses. People are reasonable if you let them be, but going down the road of:
"If you don't get vaxxed, you're stupid. Not only that, but you're morally bankrupt, and honestly should be culled from this earth."
"Ummm, no. Its just that I have some questions and reservations, and regardless of my reasons if you could speak to me as a human being and not a sub-species then I might be able to understand and come around."
"FIRE UP THE OVENS!!!"
Stop having the most polarizing figures in American deliver the message - you think they're doing that on accident? Its more divide and conquer bullshit, but they forgot that part of the unclean masses is their voter base, so....
Also, honesty. Stop fcking lying - they've already lost most if not all credibility as it is. Continuing the charade of "mask up, you'll be saving lives!!!" is insane, and not because it is only somewhat effect, but because people know that its a charade, just some are more willing to play the game than others. Notice how there have been no mask efficacy studies? We can study how "red counties are hillbilly p.o.s. people who won't get vaxxed", but nothing on whether or not masks are working. (with real numbers, none of this fuzzy math bullshit.)
Those are a few suggestions.